Translational research of cell sheet-based myocardial regeneration therapy

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منابع مشابه

[Translational research of cell sheet-based myocardial regeneration therapy].

幹 細 胞 研 究 と 臨 床 利 用 の 進 歩 3 要約:重症心不全治療として最も重要な治療法である 心臓移植は,極めて深刻なドナー不足であり,新しい 移植法案が可決されたものの,欧米レベルの汎用性の 高い治療法としての普及は困難が予想される.一方, 左室補助人工心臓(LVAD)については,日本では移植 待機期間が長期であるため,感染症や脳血栓等の合併 症が成績に大きく影響している.このような状況を克 服するため,世界的に再生医療への期待が高まってい るが,重症心不全を治癒させるまでに至らず,心臓移 植や LVADに代わる新しい治療開発が急務である.こ のような現状のなか,重症心不全においては,細胞移 植,組織移植,また再生医療的手法を用いた再生創薬 の研究がすすみ,臨床応用化が進んでいる.本稿では, これまでの筋芽細胞シートのトランスレーショナルリ サーチとともに,iPS細胞由...

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Present and Future Perspectives on Cell Sheet-Based Myocardial Regeneration Therapy

Heart failure is a life-threatening disorder worldwide and many papers reported about myocardial regeneration through surgical method induced by LVAD, cellular cardiomyoplasty (cell injection), tissue cardiomyoplasty (bioengineered cardiac graft implantation), in situ engineering (scaffold implantation), and LV restrictive devices. Some of these innovated technologies have been introduced to cl...

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Myocardial cell sheet therapy and cardiac function.

Heart failure (HF) is the leading cause of death in developed countries. Regenerative medicine has the potential to drastically improve treatment for advanced HF. Stem cell-based medicine has received attention as a promising candidate therapy over the past decade; however, it has not yet realized this potential in terms of reliability. The cell sheet is an innovative technology for constructin...

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Stem cell research and cell transplantation for myocardial regeneration.

Several human organs are not capable of functional regeneration following a tissue defect and react with scar formation. In stem cell transplantation, undifferentiated or partly differentiated precursor cells are applied to defective tissue for therapeutic regeneration. After promising preclinical investigations, the transplantation of autologous stem cells for myocardial infarction treatment i...

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Stem cell therapy for myocardial regeneration: creating hype ignoring reality.

I read with interest the recent article in European Journal of Cardio-Thoracic Surgery by Siepe and colleagues [1] where they have reviewed the work done in the field of stem cell research for myocardial regeneration. It is an excellent review paper. I would like to add a few points which unfortunately have not been addressed in this article. Despite significant advances in medical and surgical...

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ژورنال

عنوان ژورنال: Folia Pharmacologica Japonica

سال: 2016

ISSN: 0015-5691,1347-8397

DOI: 10.1254/fpj.147.269